Week in Review: New PET tracer performance | CT colonography cost-effectiveness | Animal studies

Erik Ridley Headshot

Our top story this week focused on the potential for a new PET radiotracer in imaging prostate cancer.  In phase II and phase III clinical trials, F-18 CTT1057 PET/CT was efficacious as a molecular imaging biomarker for the detection of prostate-specific membrane antigen (PSMA)-positive lesions. F-18 CTT1057 is being developed as part of a theranostics pair, and the goal is to expand treatment options for patients, according to the research team. 

Meanwhile, our second most highly-viewed articles reported on research that found CT colonography (CTC) to be more cost-effective than multitarget stool DNA testing for colorectal cancer screening. A three-year CTC surveillance strategy for small colorectal polyps and colonoscopy referral for large polyps delivered the best overall balance of cost and clinical efficacy, according to Perry Pickhardt, MD, of the University of Wisconsin in Madison, and colleagues. 

In a development that may accelerate the evaluation process and lower R&D costs, the use of animals to test PET radiotracers is being phased out. Also, serial PET/CT exams have demonstrated the value of infliximab for treating patients with refractory cardiac sarcoidosis.  

Additionally, more breast lesions can be found on MRI if an apparent diffusion coefficient (ADC) cutoff is used, according to a recent study. Other popular articles highlighted topics such as the benefits of using ultralow-dose CT in osteoporosis patients and the usefulness of high-resolution ultrasound for evaluating forearm lacerations

See below for the full list of our top stories of the week: 

  1. PET tracer performs well in clinical trial 

  2. CT colonography more cost-effective than DNA stool testing 

  3. Animal studies for PET drugs begin phasing out 

  4. PET/CT supports use of infliximab for cardiac sarcoidosis

  5. Applying ADC cutoff value finds more breast lesions on MRI 

  6. Ultralow-dose CT leads to less radiation in osteoporosis patients 

  7. High-res ultrasound useful for evaluating forearm lacerations 

  8. AI quantifies brain changes from post-CAR-T-cell therapy complication 

  9. Clairity deploys AI for breast cancer risk prediction 

  10. AI model predicts breast cancer risk in diverse population 

  11. Patient navigation lifts breast, cervical cancer screening rates 

  12. 'RadGPT' may help patients understand radiology reports

  13. Study explores PPVs of LI-RADS major feature combinations 

  14. PSMA PET/CT improves survival in men with prostate cancer 

Erik L. Ridley
Editor in Chief
AuntMinnie.com

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